Despite the popularity of diagnostic imaging tests such as CT and MRI, clinical localization is an important and necessary skill for physicians to master. This text can aid a physician with a clinical evaluation that can direct imaging studies to a specific portion of the central or peripheral nervous system. It can assist in an evaluation that is more cost-effective than functional or structural laboratory tests. Localization is important to every physician dealing with neurologic diseases, and this small guide will provide accurate, efficient and economic diagnoses of these disorders.