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| | Description | The first two editions of this title had a tremendous impact in neuroscience. Between the Second edition in 1989 and today, there has been an explosion of information in the field, including advances in molecular techniques, such as genomics and proteomics, which have become increasing important in neuroscience. A renaissance in fluorescence has occurred, driven by the development of new probes, new microscopes, live imagers, and computer processing. The introduction of new markers has enormously stimulated the field, moving it from tissue culture to neurophysiology to functional MRI techniques. | |
| | Product Details | | Hardcover: | 712 pages | | Publisher: | Springer | | Publication Date: | May 25, 2006 | | Language: | English | | ISBN: | 0387289410 | | Product Length: | 9.3 inches | | Product Width: | 6.46 inches | | Product Height: | 1.57 inches | | Product Weight: | 3.7 pounds | | Package Length: | 9.65 inches | | Package Width: | 6.69 inches | | Package Height: | 1.57 inches | | Package Weight: | 3.64 pounds | | Average Customer Rating: |  based on 3 reviews |
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| | Customer Reviews | Average Customer Review: ( 3 customer reviews )
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Most Helpful Customer Reviews
A must-have reference for anyone interested in tract tracing Oct 09, 2011
By Michael McKinnon
Introduction
This book provides a comprehensive reference for anyone interested in the various techniques used in neuronal tracing. Overall, I thought this book was very well organized. Each chapter elaborates on a specific topic related to neuroanatomical tract tracing. These chapters, written by experts in the field, each begin with an abstract and an introductory paragraph which provides a layman explanation of what the following chapter will talk about. The chapters themselves go into depth about each individual methodology, providing applications, protocols, and limitations for each. Each chapter has well defined sections and subsections, denoted by roman numerals, letters, and numbers. In addition, the multiple figures provided in the text help to explain some of the more advanced techniques. The chapters in the book progress logically, starting with molecular tools such as immunohistochemistry, later moving to single cell techniques such as the patch clamp, then to microcircuitry techniques such as viral tracers, and finally to network techniques such as computerized 3D reconstruction.
Synopsis of the book's organization
Chapter 1 is essentially a preface for the book, offering a background on previous editions of the book and the motivation for producing this new version. Chapters 2 and 3 explain immunohistochemical methods combined with TEM in order to study molecular localization in the cells. Chapter 4 moves from small molecular ligands to proteomics. Chapters 5 and 6 explain the patch clamp and other electrophysiological techniques used in studying the membrane potential of whole cells. Chapter 7 makes the jump from a single neuron to the interactions of multiple neurons by introducing synaptology. Chapters 8, 9, and 10 give various methods for tracing a single tract in vivo, including molecular and viral methods. Chapter 11 moves from single tracts to multiple tracts. Chapters 12 through 14 also talk about tract tracing. Chapters 15 and 16 move on to whole networks of neurons instead of single tracts. Finally, chapters 17-20 talk about computer analysis of neural networks, from 3D reconstruction to network modeling. The chapter list is as follows. Consult this to see if the topic you are interested in is covered by this book:
Chapter 1: Short Retrospection
Chapter 2: Preembedding Immunoelectron Microscopy: Applications for Studies of the Nervous System
Chapter 3: Postembedding Immunogold Cytochemistry of Membrane Molecules and Amino Acid Transmitters in the Central Nervous System
Chapter 4: Cell and Tissue Microdissection in Combination with Genomic and Proteomic Applications
Chapter 5: Molecules and Membrane Activity: Single-Cell RT-PCR and Patch-Clamp Recording from Central Neurons
Chapter 6: Merging Structure and Function: Combination of In Vivo Extracellular and Intracellular Electrophysiological Recordings with Neuroanatomical Techniques
Chapter 7: Juxtacellular Labelling of Individual Neurons In Vivo: From Electrophysiology to Synaptology
Chapter 8: Nonradioactive In Situ Hybridization in Combination with Tract Tracing
Chapter 9: Viral Tracers for the Analysis of Neural Circuits
Chapter 10: Dextran Amines: Versatile Tools for Anterograde and Retrograde Studies of Nervous System Connectivity
Chapter 11: Multiple Neuroanatomical Tract-Tracing: Approaches for Multiple Tract-Tracing
Chapter 12: Tract-Tracing in Developing Systems and in Postmortem Human Material Using Carbocyanide Dyes
Chapter 13: Combined Fluorescence Methods to Determine Synapses in the Light Microscope: Multilabel Confocal Laser Scanning Microscopy
Chapter 14: Advances in Understanding Cortical Function through Combined Voltage-SensitiveDye Imaging, Whole-Cell Recordings, and Analysis of Cellular Morphology
Chapter 15: From Dendrites to Networks: Optically Probing the Living Brain Slice and Using Principal Component Analysis to Characterize Neuronal Morphology
Chapter 16: Stereology of Neural Connections: An Overview
Chapter 17: Three-Dimensional Computerized Reconstruction from Serial Sections: Cell Populations, Regions, and Whole Brain
Chapter 18: Atlases of the Human Brain: Tools for Functional Neuroimaging
Chapter 19: Neuron and Network Modeling
Chapter 20: Functional Connectivity of the Brain: Reconstruction from Static and Dynamic Data
Critique
As previously stated, this is best used as a reference. While the chapter topics follow a general pattern of microscale to macroscale, it does not read as a cohesive work. Each chapter stands on its own and makes little reference to the preceding chapters. This is not necessarily a bad thing, as cohesiveness is not a requirement for reference books to be useful (i.e. the dictionary does not have a stylistic flow, but is still incredibly useful). While the introductions at the beginning of each chapter can help to ameliorate the complexity found in the body of the chapters, the chapters themselves can get very technical. They are written very much like a journal article. The methods listed in this book, while extensive, are not exhaustive. The book provides great depth on a few methods, but the selection seems almost random. Granted, it would be next to impossible to include every possible technique involved in neuroanatomical tract tracing in a single book and the book's seemingly random sampling does cover a wide area. It will however give some idea of where and how to start.
Recommendation
This book is written for those with a technical background, not those looking for a bit of light reading. This book should be found on the bookshelf in a fairly advanced neuroscience laboratory, not the nightstand of someone with a casual interest in neuroscience. I would recommend this book to the burgeoning neuroscientist who wants to include some aspect of neuroanatomy into his or her work, but is unsure about the appropriate method to do so. The book gives a great overview of the state of the art (as of 2006) and can be used to determine if your lab should go with viral tracing for neuronal microcircuitry or if you should use a more specific molecular tracer. If you want to get into electrophysiology, it will give you some background on the patch clamp technique. And once you have all of this data, it will tell you how to compile it into a computer model.
Conclusion
Overall, if you or your lab has any interest in studying the connectivity and/or morphology of neurons and neural networks, you need this book. It will, at the very least, give you an overview of some of the most widely used methods in tract tracing. The references at the end of each chapter will offer more intensive resources to test.
What comes first wiring or firing? Aug 01, 2009
By Saak Ovsepyan
"Saak V. Ovsepian"
This magnificent volume with a modest title "Neuroanatomical Tract-Tracing 3" by Prof. Zaborszky, Wouterlood and Lanciego, amalgamates into one a prosperous collection of recipes and protocols summarizing methodical wisdom and knowledge from world renowned laboratories and experts in brain science. It gives not only a detailed description of guidelines, protocols and procedures of classical neuro-anatomical methods and tract-tracing techniques but also introduces more recent concepts and tools for structural neuroscience such as viral tract-tracing, computational neuro-anatomy, functional imaging and neuronal network modeling. Each chapter (overall 20) starts with a brief and effective introduction to concept and methodology followed by meticulous recipes and applications illustrated with extensive experimental examples, literature overview and discussions. The clarity and wide scope of topics covered by this volume render it the book of choice for new and established explorers of the brain puzzle.
A good book Aug 22, 2008
By Professor Dr Jafri
"Neuron Man"
When this book arrived in our neurosciences laboratory,it was immediately swiped off the shelf by our Msc and Phd (Neurosciences) University Sains Malaysia students.They could not get enough of it.The chapters were interesting and scientifically relevant.Eveyone was looking for the previous Part 1 and 2 of the same series.
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