This book constitutes the thoroughly refereed postproceedings of the 13th International Meeting on DNA Computing, DNA 13, held in Memphis, TN, USA, June 4-8, 2007.

The 15 revised full papers and 5 short demos together with 10 poster abstracts presented were carefully selected during two rounds of reviewing and improvement from an initial total of 62 submissions. The papers are organized in topical sections on Self Assembly, Biomolecular Machines and Automata, Codes for DNA Memories and Computing, Novel Techniques for DNA Computing in Vitro, Novel Techniques for DNA Computing in Silico as well as Models and Languages.